The MRE11A Polyclonal Antibody (CAB2559) is a valuable tool for researchers studying MRE11A, a key protein involved in DNA repair and maintenance. This antibody, generated in rabbits, has high specificity and sensitivity for detecting MRE11A in human samples, making it ideal for use in Western blot applications. By binding to the MRE11A protein, this antibody enables precise detection and analysis in a variety of cell types, facilitating research in fields such as genetics, oncology, and molecular biology.MRE11A is essential for detecting and repairing DNA damage, playing a crucial role in maintaining genomic stability and preventing mutations that can lead to cancer and other diseases.
Understanding the function of MRE11A is vital for unraveling the mechanisms underlying genetic disorders and developing targeted therapies for conditions related to DNA damage and repair. The MRE11A Polyclonal Antibody is a valuable asset for researchers seeking to delve deeper into the intricate processes involved in DNA maintenance and repair.
Product Name:
MRE11 Rabbit Polyclonal Antibody
SKU:
CAB2559
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human MRE11 (NP_005582.1).
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4361
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using MRE11 Rabbit pAb (CAB2559) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
