The MRE11A Polyclonal Antibody (CAB14026) is a valuable tool for researchers studying the MRE11A protein, a key player in DNA repair pathways and genomic stability. This antibody, generated in rabbits, exhibits high specificity and sensitivity when used in Western blot applications, enabling accurate detection and analysis of MRE11A in various cell types.MRE11A is a crucial component of the MRN complex, essential for DNA double-strand break repair and the maintenance of genome integrity. Dysregulation of MRE11A has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By studying the function and expression of MRE11A using this antibody, researchers can gain valuable insights into its role in disease development and progression.Overall, the MRE11A Polyclonal Antibody (CAB14026) is a reliable tool for investigating the function and regulation of MRE11A in biological processes, offering insights that may have implications for the development of novel treatment strategies in cancer and other genetic disorders.
Product Name:
MRE11 Rabbit Polyclonal Antibody
SKU:
CAB14026
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-485 of human MRE11 (NP_005582.1).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
ATLD; HNGS1; MRE11A; MRE11B; MRE11
Positive Sample:
HeLa,Jurkat,C6
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
81kDa
Observed MW:
81kDa
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4361
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MRE11 Rabbit pAb (CAB14026) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
