MRE11 Rabbit Polyclonal Antibody (CAB14026)
- SKU:
- CAB14026
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MRE11 Rabbit Polyclonal Antibody |
SKU: | CAB14026 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-485 of human MRE11 (NP_005582.1). |
Sequence: | KGRK MNMH KIPL HTVR QFFM EDIV LANH PDIF NPDN PKVT QAIQ SFCL EKIE EMLE NAER ERLG NSHQ PEKP LVRL RVDY SGGF EPFS VLRF SQKF VDRV ANPK DIIH FFRH REQK EKTG EEIN FGKL ITKP SEGT TLRV EDLV KQYF QTAE KNVQ LSLL TERG MGEA VQEF VDKE EKDA IEEL VKYQ LEKT QRFL |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | ATLD; HNGS1; MRE11A; MRE11B; MRE11 |
Positive Sample: | HeLa,Jurkat,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 81kDa |
Observed MW: | 81kDa |
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 4361 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |