The MRC2 Polyclonal Antibody (CAB9858) is a valuable tool for research involving MRC2, a cell surface receptor involved in various physiological processes such as cell adhesion and collagen uptake. Raised in rabbits, this antibody exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the MRC2 protein, it enables precise detection and analysis in different cell types, making it ideal for studies in cell biology, tissue engineering, and extracellular matrix remodeling.
MRC2, also known as Endo180 or uPARAP, is a multifunctional receptor that plays a crucial role in the clearance of extracellular matrix components and regulation of cell invasion and migration. Its involvement in these processes makes it an important target for research in diseases related to tissue remodeling, fibrosis, and cancer metastasis. Understanding the function of MRC2 is essential for developing therapeutic strategies that target these pathways and improve clinical outcomes for patients.
Product Name:
MRC2 Rabbit Polyclonal Antibody
SKU:
CAB9858
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-300 of human MRC2 (NP_006030.2).
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.
Purification Method:
Affinity purification
Gene ID:
9902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MRC2 antibody (CAB9858) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
