The MRC1 Polyclonal Antibody (CAB8301) is a key tool for research involving the MRC1 protein, also known as mannose receptor C type 1. This cell surface receptor plays a crucial role in the immune system, specifically in the recognition and clearance of pathogens and foreign molecules. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. It binds to the MRC1 protein, enabling researchers to detect and analyze its expression in various cell types. This makes it an ideal tool for studies in immunology, infectious diseases, and cancer research.
MRC1 is involved in the regulation of immune responses, particularly in the uptake of glycoproteins and immune complexes. Its importance in pathogen recognition and immune signaling makes it a valuable target for investigation in areas such as infectious diseases, inflammation, and autoimmune disorders. Understanding the function of MRC1 is essential for the development of new therapies that target the immune system effectively. Overall, the MRC1 Polyclonal Antibody (CAB8301) is a valuable resource for researchers studying the role of MRC1 in the immune response and its implications for various disease processes.
Product Name:
Mannose Receptor/CD206 Polyclonal Antibody
SKU:
CAB8301
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 610-860 of human Mannose Receptor/CD206 (NP_002429.1).
Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Calculated MW:
166kDa
Observed MW:
190-250kDa
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.
Purification Method:
Affinity purification
Gene ID:
4360
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Mannose Receptor/CD206 Rabbit pAb (CAB8301) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Negative control (NC): Jurkat.Exposuretime: 30s.
