The MRAP2 Polyclonal Antibody (PACO39834) is a valuable tool for researchers studying MRAP2, a protein associated with the regulation of melanocortin receptor signaling and energy homeostasis. This antibody, developed in rabbits, exhibits high specificity for human samples and has been validated for use in applications such as Western blotting.MRAP2, also known as melanocortin-2 receptor accessory protein 2, plays a crucial role in modulating the activity of melanocortin receptors, which are involved in various physiological processes, including energy balance and stress response.
Research into MRAP2 function has implications for understanding obesity, metabolic disorders, and endocrine diseases.By targeting the MRAP2 protein, researchers can gain insights into its role in regulating melanocortin receptor signaling and potential implications for metabolic health. The MRAP2 Polyclonal Antibody (PACO39834) is a reliable tool for investigating MRAP2 function in various cell types and tissues, making it a valuable asset for studies in the fields of endocrinology and metabolism.
Western blot. All lanes: MRAP2 antibody at 7µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24 kDa. Observed band size: 24 kDa.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO39834 at dilution of 1:100.
Immunofluorescent analysis of U251 cells using PACO39834 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Synonyms:
Melanocortin-2 receptor accessory protein 2 (MC2R accessory protein 2), MRAP2, C6orf117
UniProt Protein Function:
MRAP2: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. Belongs to the MRAP family. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5RChromosomal Location of Human Ortholog: 6q14.2Cellular Component: endoplasmic reticulum; plasma membraneMolecular Function: adrenocorticotropin hormone receptor binding; identical protein binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor bindingBiological Process: energy reserve metabolic process; feeding behavior; positive regulation of cAMP biosynthetic processDisease: Body Mass Index Quantitative Trait Locus 18
