The MR1 Polyclonal Antibody (CAB8051) is a valuable tool for researchers studying the MR1 protein, a key player in the immune system's response to microbial infections. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By targeting the MR1 protein, this antibody allows for the detection and analysis of MR1 in various cell types, making it an essential component for studies in immunology and infectious disease research.The MR1 protein is a major histocompatibility complex (MHC)-like molecule that presents vitamin B metabolites to mucosal-associated invariant T (MAIT) cells, a specialized group of T cells involved in immunity against bacterial threats.
Understanding the function of MR1 is crucial for developing new strategies to enhance immune responses and combat infectious diseases. The MR1 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of MR1 in immune surveillance and defense mechanisms, paving the way for innovative approaches in immunotherapy and vaccine development.
Product Name:
MR1 Rabbit Polyclonal Antibody
SKU:
CAB8051
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-291 of human MR1 (NP_001522.1).
Cell membrane, Endoplasmic reticulum, Endoplasmic reticulum membrane, Extracellular side, Secreted, Single-pass membrane protein, Single-pass type I membrane protein.
Calculated MW:
39kDa
Observed MW:
39kDa
MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome.
Purification Method:
Affinity purification
Gene ID:
3140
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MR1 antibody (CAB8051) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
