The MPP6 Polyclonal Antibody (PAC020846) is a valuable tool for researchers studying MPP6, a key protein involved in RNA processing and transport. This antibody, developed in rabbits, shows high specificity and sensitivity in detecting MPP6 in human samples, making it an ideal choice for Western blot applications.MPP6 is an essential component of the RNA exosome complex, which is responsible for degrading and processing various RNA molecules within the cell. Its function in regulating RNA turnover and maintaining RNA stability highlights its importance in gene expression and cellular function.
By targeting MPP6 with this antibody, researchers can gain insights into its role in RNA metabolism and potentially uncover new therapeutic targets for diseases related to RNA dysregulation.This antibody can be utilized in a wide range of cell types and experimental conditions, offering versatile applications in molecular biology, biochemistry, and biomedical research. Its high specificity and sensitivity ensure reliable and reproducible results, making it a valuable asset for studies focusing on RNA biology, gene expression, and disease mechanisms.
Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20846(MPP6 Antibody) at dilution 1/250 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20846(MPP6 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).
Synonyms:
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
UniProt Protein Function:
VAM-1: a membrane-associated of the MAGUK family. Interacts with Lin7, which localizes to postsynaptic densities of neurons and epithelial cell-cell junctions.
UniProt Protein Details:
Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7p15
Molecular Function:protein binding
NCBI Summary:
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
