The MPP1 Polyclonal Antibody (CAB6298) is a valuable tool for researchers studying the MPP1 protein, which plays a crucial role in maintaining membrane structure and function in red blood cells and other tissues. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.MPP1, also known as palmitoylated membrane protein 1, is involved in the organization of membrane domains and contributes to cell membrane stability. Dysregulation of MPP1 expression has been linked to various diseases, including hereditary spherocytosis and certain types of cancer.
The MPP1 Polyclonal Antibody allows for accurate detection and analysis of MPP1 protein levels in a variety of cell types, making it an invaluable tool for research in cell biology and disease pathology.Researchers studying membrane dynamics, red blood cell disorders, and cancer biology will benefit from the specificity and sensitivity of the MPP1 Polyclonal Antibody for their experiments. By gaining a better understanding of the function and regulation of MPP1, scientists can uncover new therapeutic targets and develop novel treatment strategies for a range of diseases.
Product Name:
MPP1 Rabbit Polyclonal Antibody
SKU:
CAB6298
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MPP1 (NP_002427.1).
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4354
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MPP1 antibody (CAB6298) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 60s.
