The mPhosph8 Antibody (PACO10553) is a highly specific tool for researchers studying phosphorylated proteins involved in cell signaling pathways. This rabbit polyclonal antibody is optimized for detecting phosphorylation at the Serine 8 residue, making it a valuable tool for studying protein activation and regulation.Its high reactivity with human samples and validation for use in Western blot applications make it a reliable choice for researchers looking to study phosphorylation events in various cell types. By targeting the phosphorylated form of proteins, the mPhosph8 Antibody enables researchers to gain insights into important cellular processes such as cell growth, differentiation, and responses to external stimuli.
The mPhosph8 Antibody is a valuable tool for researchers in molecular biology, cell biology, and cancer research, providing a deeper understanding of the signaling events that drive cellular function and disease progression. Its specificity and sensitivity make it a key component in studying the intricate mechanisms underlying various cellular processes.
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
