Mouse TRAIL Recombinant Protein (RPPB1057)
- SKU:
- RPPB1057
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P50592
- Research Area:
- Cytokines
Description
| Product Name: | Mouse TRAIL Recombinant Protein |
| Product Code: | RPPB1057 |
| Size: | 50µg |
| Species: | Mouse |
| Target: | TRAIL |
| Synonyms: | Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL, Apo-2 ligand, Apo-2L, CD253 antigen, TL2, APO2L, TNFSF10.� |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized containing PBS, pH 7.4, and 3mM DTT. |
| Solubility: | It is recommended to reconstitute the lyophilized TRAIL Mouse Recombinant in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions.� |
| Stability: | Lyophilized TRAIL although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TRAIL recombinant should be stored at 4C between 2-7 days and for future use below -18C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MPRGGRPQKV AAHITGITRR SNSALIPISK DGKTLGQKIE SWESSRKGHS FLNHVLFRNG ELVIEQEGLY YIYSQTYFRF QEAEDASKMV SKDKVRTKQL VQYIYKYTSY PDPIVLMKSA RNSCWSRDAE YGLYSIYQGG LFELKKNDRI FVSVTNEHLM DLDQEASFFG AFLIN� |
| Biological Activity: | Fully biologically active when compared to standard. The ED50 as determined by a cytotoxicity assay using murine L929 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2,000,000 IU/mg in the presence of actinomycin D. |
TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.In humans, the gene that encodes for TRAIL is located at chromosome 3q26. TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.
TRAIL Recombinant Mouse produced in E.coli is a single, non-glycosylated polypeptide chain containing 175 amino acids and having a molecular mass of 20.2kDa.�
| UniProt Protein Function: | TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Membrane protein, integral Cellular Component: extracellular space; membrane; integral to membrane Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding Biological Process: apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; immune response |
| UniProt Code: | P50592 |
| NCBI GenInfo Identifier: | 1730016 |
| NCBI Gene ID: | 22035 |
| NCBI Accession: | P50592.1 |
| UniProt Related Accession: | P50592 |
| Molecular Weight: | 33,477 Da |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 10 |
| NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 10 |
| NCBI Official Symbol: | Tnfsf10�� |
| NCBI Official Synonym Symbols: | TL2; Ly81; Trail; APO-2L; AI448571; A330042I21Rik�� |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 10; TRAIL/APO2L; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 10 |
| UniProt Synonym Protein Names: | TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253 |
| UniProt Gene Name: | Tnfsf10�� |
| UniProt Entry Name: | TNF10_MOUSE |
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