Mouse TIE1 Fc Recombinant Protein (RPPB2666)
- SKU:
- RPPB2666
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q06806
- Research Area:
- Enzymes
Description
| Product Name: | Mouse TIE1 Fc Recombinant Protein |
| Product Code: | RPPB2666 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | TIE1 Fc |
| Synonyms: | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1, JTK14, TIE, TIE1. |
| Source: | Chinese Hamster Ovary Cells (CHO) |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | TIE-1 Fc Chimera was lyophilized from a concentrated (1mg/ml) sterile solution containing 1x PBS. |
| Solubility: | It is recommended to reconstitute the lyophilized TIE-1 Fc Chimera in sterile water not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized sTIE-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TIE-1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.
Soluble TIE-1 Mouse Recombinant fused with the Fc part of human IgG1 produced in CHO cells is a glycosylated disulfide-linked homodimeric polypeptide chain containing amino acids 23-749 and having a total molecular mass of 260kDa. The Mouse TIE-1/Fc monomer has a calculated molecular mass of approximately 105kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 130kDa protein in SDS-PAGE under reducing conditions.The TIE1 Fc Chimera is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TIE1: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; TK group; Tie family Cellular Component: integral to membrane; plasma membrane Biological Process: blood vessel development; in utero embryonic development; negative regulation of angiogenesis; negative regulation of cell migration; plasma membrane fusion; response to retinoic acid; vasculogenesis |
| UniProt Code: | Q06806 |
| NCBI GenInfo Identifier: | 342187134 |
| NCBI Gene ID: | 21846 |
| NCBI Accession: | Q06806.3 |
| UniProt Secondary Accession: | Q06806,Q811F4, Q8BGI2, |
| UniProt Related Accession: | Q06806 |
| Molecular Weight: | 124,583 Da |
| NCBI Full Name: | Tyrosine-protein kinase receptor Tie-1 |
| NCBI Synonym Full Names: | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 |
| NCBI Official Symbol: | Tie1�� |
| NCBI Official Synonym Symbols: | TIE; tie-1; D430008P04Rik�� |
| NCBI Protein Information: | tyrosine-protein kinase receptor Tie-1 |
| UniProt Protein Name: | Tyrosine-protein kinase receptor Tie-1 |
| Protein Family: | Tyrosine-protein kinase receptor |
| UniProt Gene Name: | Tie1�� |
| UniProt Entry Name: | TIE1_MOUSE |
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