The Mouse TCR Monoclonal Antibody (PE/Cyanine5 Conjugated) H57-597 (HB218) (AGEL1541) is a powerful tool for researchers studying T cell receptor (TCR) signaling and function. This monoclonal antibody, conjugated to PE/Cyanine5, specifically targets the TCR complex, allowing for precise detection and analysis in experimental settings.The TCR is a key player in the adaptive immune response, facilitating the recognition of antigens presented by major histocompatibility complexes (MHCs) on antigen-presenting cells. The H57-597 (HB218) antibody is meticulously designed to bind to the TCR, enabling researchers to study T cell activation, differentiation, and signaling pathways with high specificity and sensitivity.
This antibody is a valuable resource for investigating T cell behavior in various biological contexts, including immunology, infectious diseases, and cancer research. By targeting the TCR complex, researchers can gain valuable insights into T cell function and the mechanisms underlying immune responses, paving the way for enhanced understanding of immune-related disorders and the development of novel therapeutic strategies.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Gene ID:
21577
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR-β is a member of the immunoglobulin superfamily and a component of the CD3/TCR complex (along with TCR-α). It is expressed on α/β TCR-bearing T cells and thymocytes. The CD3/TCR complex plays a key role in antigen recognition, signal transduction, and T cell activation.