The Mouse TCR Monoclonal Antibody (Biotin Conjugated) H57-597 (HB218) is a versatile research tool designed for the detection and analysis of T cell receptor (TCR) molecules in mouse samples. This antibody, produced through monoclonal technology, specifically targets the TCR complex, a key player in the antigen recognition process of T cells, allowing for precise identification and characterization of T cell subsets.TCRs are essential components of the adaptive immune system, responsible for recognizing and binding to antigens presented by major histocompatibility complexes (MHCs) on antigen-presenting cells.
The H57-597 (HB218) antibody is conjugated with biotin, facilitating easy and efficient detection through various detection methods, such as flow cytometry and immunohistochemistry.By utilizing this antibody, researchers can gain valuable insights into T cell activation, differentiation, and function, advancing studies in immunology, autoimmunity, infectious diseases, and cancer immunotherapy. The specificity and reliability of the H57-597 (HB218) antibody make it an indispensable tool for investigating the intricacies of T cell biology and its implications in health and disease.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Gene ID:
21577
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR-β is a member of the immunoglobulin superfamily and a component of the CD3/TCR complex (along with TCR-α). It is expressed on α/β TCR-bearing T cells and thymocytes. The CD3/TCR complex plays a key role in antigen recognition, signal transduction, and T cell activation.