Mouse Rantes Recombinant Protein (RPPB1243)
- SKU:
- RPPB1243
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P30882
- Research Area:
- Chemokines
Frequently bought together:
Description
| Product Name: | Mouse Rantes Recombinant Protein |
| Product Code: | RPPB1243 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | Rantes |
| Synonyms: | Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine (C-C motif) ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Filtered (0.2�m) and lyophilized from a solution in 2�PBS, pH7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Rantes in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Mouse Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL5 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS |
| Biological Activity: | The activity is determined by the ability to chemoattract total human lymphocytes population at a concentration between 1-10ng/ml. |
Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites.
Rantes Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7.8kDa. The Mouse Rantes is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL5: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. By mitogens. T-cell and macrophage specific. Belongs to the intercrine beta (chemokine CC) family.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Chemokine; Cell adhesionCellular Component: extracellular space; cell; cytoplasm; extracellular region; intracellularMolecular Function: heparin binding; CCR1 chemokine receptor binding; protein homodimerization activity; protein self-association; chemokine activity; chemokine receptor binding; chemokine receptor antagonist activity; cytokine activity; receptor signaling protein tyrosine kinase activator activity; phosphoinositide phospholipase C activity; CCR5 chemokine receptor binding; phospholipase activator activity; protein kinase activity; chemoattractant activityBiological Process: exocytosis; positive regulation of cell adhesion; positive regulation of osteoclast differentiation; response to toxin; positive regulation of smooth muscle cell proliferation; chemotaxis; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of homotypic cell-cell adhesion; pseudopodium formation; leukocyte adhesion; cell-cell signaling; positive chemotaxis; calcium ion transport; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; positive regulation of T cell proliferation; inflammatory response; lymphocyte chemotaxis; protein tetramerization; phospholipase D activation; neutrophil activation; negative regulation of G-protein coupled receptor protein signaling pathway; MAPKKK cascade; positive regulation of cellular biosynthetic process; cellular calcium ion homeostasis; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cellular protein complex assembly; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of viral genome replication; response to cytokine stimulus; eosinophil chemotaxis; positive regulation of fever; immune response; positive regulation of neuron differentiation; positive regulation of calcium ion transport; positive regulation of defense response to virus by host; regulation of insulin secretion; positive regulation of epithelial cell proliferation; positive regulation of phosphorylation; positive regulation of cell migration; regulation of T cell activation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P30882 |
| NCBI GenInfo Identifier: | 548926 |
| NCBI Gene ID: | 20304 |
| NCBI Accession: | P30882.2 |
| UniProt Secondary Accession: | P30882 |
| UniProt Related Accession: | P30882 |
| Molecular Weight: | 10,071 Da |
| NCBI Full Name: | C-C motif chemokine 5 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 5 |
| NCBI Official Symbol: | Ccl5�� |
| NCBI Official Synonym Symbols: | SISd; Scya5; RANTES; TCP228; MuRantes�� |
| NCBI Protein Information: | C-C motif chemokine 5; SIS-delta; small inducible cytokine A5; small-inducible cytokine A5; T-cell-specific protein RANTES |
| UniProt Protein Name: | C-C motif chemokine 5 |
| UniProt Synonym Protein Names: | MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Ccl5�� |
| UniProt Entry Name: | CCL5_MOUSE |
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