Mouse PRDX1 Recombinant Protein (RPPB2175)
- SKU:
- RPPB2175
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P35700
- Research Area:
- Enzymes
Description
| Product Name: | Mouse PRDX1 Recombinant Protein |
| Product Code: | RPPB2175 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | PRDX1 |
| Synonyms: | Peroxiredoxin-1, Macrophage 23 kDa stress protein, Osteoblast-specificfactor 3, OSF-3, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxidereductase 2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PRDX1 protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSSGNAKIGY PAPNFKATAV MPDGQFKDIS LSEYKGKYVV FFFYPLDFTFVCPTEIIAFS DRADEFKKLN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLISDPKR TIAQDYGVLKADEGISFRGL FIIDDKGILR QITINDLPVG RSVDEIIRLV QAFQFTDKHG EVCPAGWKPGSDTIKPDVNK SKEYFSKQKL EHHHHHH |
| Biological Activity: | Specific activity is >2,500 pmol/min/ug. Enzymaticactivity is defined as the amount of hydroperoxide that 1ug of enzyme canreduce at 25�C for minute. |
PRDX1 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX1 is an important protector of red blood cells against reactive oxygen species and in tumor prevention.PRDX1 is antioxidant protective in cells, and contributes to the antiviral activity of CD8(+) T-cells. PRDX1 has a proliferative effect and is involved in cancer development or progression.Peroxiredoxin-1 is plays a role in redox regulation of the cell. Peroxiredoxin decreases peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. Peroxiredoxin is involved in eliminating peroxides generated during metabolism. Peroxiredoxin participates in the signaling cascades of growth factors and TNF-alpha by regulating the intracellular concentrations of h(2)o(2).
PRDX1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 207 amino acids (1-199a.a.) and having a molecular mass of 23.2kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).PRDX1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Nuclear receptor co-regulator; EC 1.11.1.15 Cellular Component: peroxisomal matrix; extracellular space; mitochondrion; mitochondrial matrix; cytoplasm; nucleolus; cytosol; nucleus; myelin sheath Molecular Function:antioxidant activity; identical protein binding; protein binding; peroxidase activity; protein homodimerization activity; peroxiredoxin activity; thioredoxin peroxidase activity; heme binding; oxidoreductase activity Biological Process: regulation of stress-activated MAPK cascade; erythrocyte homeostasis; cell proliferation; response to reactive oxygen species; removal of superoxide radicals; natural killer cell mediated cytotoxicity; hydrogen peroxide catabolic process; response to oxidative stress; regulation of NF-kappaB import into nucleus |
| UniProt Code: | P35700 |
| NCBI GenInfo Identifier: | 6754976 |
| NCBI Gene ID: | 18477 |
| NCBI Accession: | NP_035164.1 |
| UniProt Secondary Accession: | P35700,Q3UBV4, Q9CWI2, |
| UniProt Related Accession: | P35700 |
| Molecular Weight: | 22,176 Da |
| NCBI Full Name: | peroxiredoxin-1 |
| NCBI Synonym Full Names: | peroxiredoxin 1 |
| NCBI Official Symbol: | Prdx1�� |
| NCBI Official Synonym Symbols: | PAG; OSF3; Paga; PrxI; TDX2; TPxA; prx1; MSP23; NkefA; OSF-3; PrdxI; Tdpx2�� |
| NCBI Protein Information: | peroxiredoxin-1; thioredoxin peroxidase 2; osteoblast specific factor 3; osteoblast-specific factor 3; macrophage 23 Kd stress protein; macrophage 23kDa stress protein; macrophase stress protein 22kDa; macrophase stress protein 23 kd; proliferation-associated gene A; macrophage 23 kDa stress protein; Trx dependent peroxide reductase 2; thioredoxin dependent peroxide reductase 2; thioredoxin-dependent peroxide reductase 2 |
| UniProt Protein Name: | Peroxiredoxin-1 |
| UniProt Synonym Protein Names: | Macrophage 23 kDa stress protein; Osteoblast-specific factor 3; OSF-3; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2 |
| Protein Family: | Peroxiredoxin |
| UniProt Gene Name: | Prdx1�� |
| UniProt Entry Name: | PRDX1_MOUSE |
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