Mouse OSM Recombinant Protein (RPPB0826)
- SKU:
- RPPB0826
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P53347
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse OSM Recombinant Protein |
| Product Code: | RPPB0826 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | OSM |
| Synonyms: | Oncostatin-M, OSM, OncoM. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | OSM protein was lyophilized from a 0.2�m filtered concentrated solution in 1xPBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Oncostatin M in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Oncostatin M although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Oncostatin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | NRGCSNSSSQ LLSQLQNQAN LTGNTESLLE PYIRLQNLNT PDLRAACTQH SVAFPSEDTL RQLSKPHFLS TVYTTLDRVL YQLDALRQKF LKTPAFPKLD SARHNILGIR NNVFCMARLL NHSLEIPEPT QTDSGASRST TTPDVFNTKI GSCGFLWGYH RFMGSVGRVF REWDDGSTRS R |
| Biological Activity: | The ED50 as determined by the dose-dependent stimulation of the proliferation of NIH-3T3 mouse embryonic fibroblast cells is < 1 ng/ml, corresponding to a specific activity of > 1.0�106 units/mg. |
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.
OSM Mouse Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 181 amino acids and having a molecular mass of 20.4kDa.The OSM is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11 A1|11 2.94 cM Cellular Component: extracellular region; extracellular space Molecular Function:cytokine activity; growth factor activity; oncostatin-M receptor binding Biological Process: behavioral response to pain; immune response; negative regulation of cell proliferation; negative regulation of hormone secretion; negative regulation of meiotic nuclear division; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of STAT protein; regulation of growth; response to heat; tyrosine phosphorylation of STAT protein |
| UniProt Code: | P53347 |
| NCBI GenInfo Identifier: | 61656173 |
| NCBI Gene ID: | 18413 |
| NCBI Accession: | NP_001013383.1 |
| UniProt Secondary Accession: | P53347,Q3U1Y5, Q5SPX6, |
| UniProt Related Accession: | P53347 |
| Molecular Weight: | 30,114 Da |
| NCBI Full Name: | oncostatin-M |
| NCBI Synonym Full Names: | oncostatin M |
| NCBI Official Symbol: | Osm�� |
| NCBI Official Synonym Symbols: | OncoM�� |
| NCBI Protein Information: | oncostatin-M |
| UniProt Protein Name: | Oncostatin-M |
| Protein Family: | Oncostatin |
| UniProt Gene Name: | Osm�� |
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