Mouse NT 3 Recombinant Protein (RPPB0800)
- SKU:
- RPPB0800
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P20181
- Research Area:
- Neurotrophins
Description
| Product Name: | Mouse NT 3 Recombinant Protein |
| Product Code: | RPPB0800 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | NT 3 |
| Synonyms: | Neurotrophic factor, Nerve growth factor-2, NGF-2, HDNF, NT-3, Neurotrophin-3, Ntf3, Ntf-3, AI316846, AI835689, Nt3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from 0.02% TFA. |
| Solubility: | It is recommended to reconstitute the lyophilized Neurotrophin-3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized NGF2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NGF-2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | YAEHKSHRGE YSVCDSESLW VTDKSSAIDI RGHQVTVLGE IKTGNSPVKQ YFYETRCKEA RPVKNGCRGI DDKHWNSQCK TSQTYVRALT SENNKLVGWR WIRIDTSCVC ALSRKIGRT |
| Biological Activity: | The activity, as determined by the dose-dependent proliferation of BaF3 cells transfected with the TrkB receptor, is typically in the range of 1-10 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg. |
NT3 a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
Neurotrophin-3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids and having a molecular mass of 13.6kDa. The NT-3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region Molecular Function:neurotrophin p75 receptor binding; neurotrophin receptor binding; protein binding; growth factor activity; nerve growth factor binding; chemoattractant activity; receptor binding Biological Process: myelination; axon guidance; mechanoreceptor differentiation; epidermis development; glial cell fate determination; activation of MAPK activity; regulation of neuron differentiation; positive regulation of receptor internalization; positive regulation of glial cell differentiation; enteric nervous system development; induction of positive chemotaxis; positive chemotaxis; regulation of neuron apoptosis; positive regulation of cell proliferation; negative regulation of neuron apoptosis; regulation of synaptic transmission; nervous system development; negative regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase B; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system development; positive regulation of peptidyl-tyrosine phosphorylation; generation of neurons; neuromuscular synaptic transmission; neuron development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; nerve development; brain development; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration |
| UniProt Code: | P20181 |
| NCBI GenInfo Identifier: | 128582 |
| NCBI Gene ID: | 18205 |
| NCBI Accession: | P20181.1 |
| UniProt Related Accession: | P20181 |
| Molecular Weight: | 29,588 Da |
| NCBI Full Name: | Neurotrophin-3 |
| NCBI Synonym Full Names: | neurotrophin 3 |
| NCBI Official Symbol: | Ntf3�� |
| NCBI Official Synonym Symbols: | Nt3; Ntf-3; AI316846; AI835689�� |
| NCBI Protein Information: | neurotrophin-3; HDNF; NGF-2; neurotrophic factor; nerve growth factor 2 |
| UniProt Protein Name: | Neurotrophin-3 |
| UniProt Synonym Protein Names: | HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor |
| Protein Family: | Neurotrophin |
| UniProt Gene Name: | Ntf3�� |
| UniProt Entry Name: | NTF3_MOUSE |
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