Mouse MIP 1b Recombinant Protein (RPPB1218)
- SKU:
- RPPB1218
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P14097
- Research Area:
- Chemokines
Description
| Product Name: | Mouse MIP 1b Recombinant Protein |
| Product Code: | RPPB1218 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | MIP 1b |
| Synonyms: | Small inducible cytokine A4, CCL4, Macrophage inflammatory protein 1-beta, MIP-1- beta, MIP-1-beta(1-69), T-cell activation protein 2, ACT-2, PAT 744, H400, SIS-gamma, Lymphocyte activation gene 1 protein, LAG-1, HC21, G-26 T-lymphocyte-secreted protein, chemokine (C-C motif) ligand 4, ACT2, G-26, LAG1, MIP1B, SCYA2, SCYA4, AT744.1, MGC104418, MGC126025, MGC126026. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1 mg/ml) solution in water containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Mouse MIP-1b in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Mouse MIP-1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Mouse CCL4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA |
| Biological Activity: | Mouse MIP-1 beta activity is calculated by the ability to chemoattract Human blood monocytes at 20-100ng/ml corresponding to a Specific Activity of 10,000-50,000IU/mg. |
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines.
Macrophage Inflammatory Protein-1 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7808 Dalton. The MIP-1b is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function:identical protein binding; protein binding; CCR1 chemokine receptor binding; chemokine activity; cytokine activity; CCR5 chemokine receptor binding Biological Process: leukocyte chemotaxis; response to toxin; immune response; positive regulation of calcium-mediated signaling; positive regulation of tumor necrosis factor production; inflammatory response; chemotaxis; positive regulation of calcium ion transport; positive regulation of vascular permeability |
| UniProt Code: | P14097 |
| NCBI GenInfo Identifier: | 1346534 |
| NCBI Gene ID: | 20303 |
| NCBI Accession: | P14097.3 |
| UniProt Related Accession: | P14097 |
| Molecular Weight: | 10,168 Da |
| NCBI Full Name: | C-C motif chemokine 4 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 4 |
| NCBI Official Symbol: | Ccl4�� |
| NCBI Official Synonym Symbols: | Act-2; Mip1b; Scya4; MIP-1B; AT744.1�� |
| NCBI Protein Information: | C-C motif chemokine 4; ACT2; SIS-gamma; MIP-1 beta; MIP-1-beta; immune activation protein 2; small inducible cytokine A4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta |
| UniProt Protein Name: | C-C motif chemokine 4 |
| UniProt Synonym Protein Names: | Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Ccl4�� |
| UniProt Entry Name: | CCL4_MOUSE |
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