Mouse MIP 1a Recombinant Protein (RPPB1215)
- SKU:
- RPPB1215
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P10855
- Research Area:
- Chemokines
Description
| Product Name: | Mouse MIP 1a Recombinant Protein |
| Product Code: | RPPB1215 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | MIP 1a |
| Synonyms: | Small inducible cytokine A3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, Tonsillar lymphocyte LD78 alpha protein, G0/G1 switch regulatory protein 19-1, G0S19-1 protein, SIS-beta, PAT 464.1, chemokine (C-C motif) ligand 3, MIP1A, SCYA3, G0S19-1, LD78ALPHA, TY-5, SIS-alpha, Heparin-binding chemotaxis protein, L2G25B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MIP-1a protein solution (0.5mg/ml) containing 20mM Sodium citrate buffer (pH 3.5) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAPYGAD TPTACCFSYS RKIPRQFIVD YFETSSLCSQ PGVIFLTKRN RQICADSKET WVQEYITDLE LNA |
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.
MIP-1a Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 93 amino acids (24-92 a.a.) and having a molecular mass of 10.4kDa.MIP-1a is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis Cellular Component: extracellular space; cell; extracellular region; cytosol Molecular Function:protein binding; chemokine activity; cytokine activity Biological Process: neutrophil chemotaxis; positive regulation of osteoclast differentiation; leukocyte chemotaxis; positive regulation of interleukin-1 beta secretion; positive regulation of tumor necrosis factor production; chemotaxis; macrophage chemotaxis; regulation of cell shape; elevation of cytosolic calcium ion concentration; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response; astrocyte cell migration; positive regulation of inflammatory response |
| UniProt Code: | P10855 |
| NCBI GenInfo Identifier: | 127079 |
| NCBI Gene ID: | 20302 |
| NCBI Accession: | P10855.2 |
| UniProt Secondary Accession: | P10855,P14096, |
| UniProt Related Accession: | P10855 |
| Molecular Weight: | 10,345 Da |
| NCBI Full Name: | C-C motif chemokine 3 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 3 |
| NCBI Official Symbol: | Ccl3�� |
| NCBI Official Synonym Symbols: | Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha�� |
| NCBI Protein Information: | C-C motif chemokine 3; TY-5; L2G25B; MIP1 (a); SIS-alpha; MIP-1 alpha; MIP-1-alpha; small inducible cytokine A3; small-inducible cytokine A3; heparin-binding chemotaxis protein; macrophage inflammatory protein-1alpha; macrophage inflammatory protein 1-alpha |
| UniProt Protein Name: | C-C motif chemokine 3 |
| UniProt Synonym Protein Names: | Heparin-binding chemotaxis protein; L2G25B; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; SIS-alpha; Small-inducible cytokine A3; TY-5 |
| Protein Family: | C-C motif chemokine |
| UniProt Gene Name: | Ccl3�� |
| UniProt Entry Name: | CCL3_MOUSE |
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