The Mouse LY-6G/LY-6C/GR-1 Monoclonal Antibody (AF647 Conjugated, RB6-8C5, AGEL1488) is a powerful tool for researchers studying immune cells in mice. This antibody specifically targets the LY-6G, LY-6C, and GR-1 proteins, which are commonly used as markers for myeloid-derived suppressor cells and neutrophils in the immune system. The AF647 conjugation allows for easy visualization and detection of these proteins, making it ideal for flow cytometry and immunofluorescence applications. With the RB6-8C5 clone specificity, researchers can confidently identify and study these important cell populations in various tissues and experimental models.
Understanding the role of LY-6G, LY-6C, and GR-1 in immune responses is crucial for investigating inflammation, infection, and cancer progression. This monoclonal antibody provides a reliable tool for in-depth analysis of these critical immune cell subsets, opening up new possibilities for research in immunology and related fields.
Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:
Liquid
Conjugation:
Genie Fluor647
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P35461 P0CW03
Gene ID:
546644 ,17067
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
Gr-1 is a 21-25 kD protein also known as Ly-6G/Ly-6C. This myeloid differentiation antigen is a glycosylphosphatidylinositol (GPI)-linked protein expressed on granulocytes and macrophages. In bone marrow, the expression levels of Gr-1 directly correlate with granulocyte differentiation and maturation; Gr-1 is also transiently expressed on bone marrow cells in the monocyte lineage. Immature Myeloid Gr-1+ cells play a role in the development of antitumor immunity.
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