Mouse LGALS4 Recombinant Protein (RPPB0283)
- SKU:
- RPPB0283
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q8K419
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Mouse LGALS4 Recombinant Protein |
| Product Code: | RPPB0283 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | LGALS4 |
| Synonyms: | gal-4 , Galectin-4, Lactose-binding lectin 4, lectin galactoside-binding soluble 4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LGALS4 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAYVPAP GYQPTYNPTL PYKRPIPGGL SVGMSVYIQG MAKENMRRFH VNFAVGQDDG ADVAFHFNPR FDGWDKVVFN TMQSGQWGKE EKKKSMPFQK GKHFELVFMV MPEHYKVVVN GNSFYEYGHR LPVQMVTHLQ VDGDLELQSI NFLGGQPAAA PYPGAMTIPA YPAGSPGYNP PQMNTLPVMT GPPVFNPRVP YVGALQGGLT VRRTIIIKGY VLPTARNFVI NFKVGSSGDI ALHLNPRIGD SVVRNSFMNG SWGAEERKVA YNPFGPGQFF DLSIRCGMDR FKVFANGQHL FDFSHRFQAF QMVDTLEING DITLSYVQI |
| Biological Activity: | The ED50 was measured by its ability to agglutinate human red blood cells and was found to be <5 ug/ml. |
Galectin-4 is a member of the subfamily of galectins composed of two carbohydrate recognition domains having similar peptide chains. The galectins are a family of beta-galactoside-binding proteins having a role in modulating cell-cell and cell-matrix interactions, which inhibits chronic inflammations, GVHD, and allergic responses. LGALS4 expression is limited to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. LGALS4 binds as an endogenous ligand to glycosphingolipids having 3-O-sulfated Gal residues and bind as well to cholesterol-3-sulfate. LGALS4 takes part in cell adhesion. LGALS4 plays a role in crosslinking the lateral cell membranes of the surface-lining epithelial cells, thus supporting epithelial integrity against mechanical stress exerted by the bowel lume. LGALS4 is in charge of intestinal inflammation via selective regulation of peripheral and mucosal T-cell cell cycle, in addition to cell death by apoptosis of T-cells by a pathway independent of the activation of caspases. LGALS4 blockade decreases TNF-alpha inhibitor induced T-cell death. LGALS4 decreases pro-inflammatory cytokine secretion including IL-6 & IL-17.
LGALS4 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-326a.a) and having a molecular mass of 38.8kDa.LGALS4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Galectin that binds lactose and a related range of sugars. |
| UniProt Code: | Q8K419 |
| NCBI GenInfo Identifier: | 46849705 |
| NCBI Gene ID: | 16855 |
| NCBI Accession: | NP_034836.1 |
| UniProt Secondary Accession: | Q8K419,O88353, Q91X74, |
| UniProt Related Accession: | Q8K419 |
| Molecular Weight: | 36,372 Da |
| NCBI Full Name: | galectin-4 |
| NCBI Synonym Full Names: | lectin, galactose binding, soluble 4 |
| NCBI Official Symbol: | Lgals4�� |
| NCBI Official Synonym Symbols: | gal-4�� |
| NCBI Protein Information: | galectin-4 |
| UniProt Protein Name: | Galectin-4 |
| UniProt Synonym Protein Names: | Lactose-binding lectin 4 |
| Protein Family: | Gallinacin |
| UniProt Gene Name: | Lgals4�� |
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