Mouse Immune Cell Specific Depletion Antibodies

Cell-specific depletion refers to the selective removal or reduction of a specific type of cell within a population. This process can be achieved through various techniques such as genetic manipulation, antibody-based methods, or pharmacological inhibitors. The goal of cell-specific depletion is to study the function and contribution of specific cell types to the overall physiology of a tissue or organism. This approach has been widely used in the field of biological research to gain insights into cellular signaling pathways, disease pathogenesis, and to test potential therapeutic strategies.

Cell-specific depletion using antibodies involves targeting a specific cell type with an antibody that recognizes a unique protein expressed on the surface or within the cell. The antibody can then bind to its target, leading to the removal of the cell through a process known as antibody-mediated cell death. This can occur via activation of the immune system, such as through complement-mediated cytotoxicity or antibody-dependent cellular phagocytosis, or through direct induction of apoptosis. Antibody-based cell depletion has been widely used in basic research to study the contribution of specific cell types to physiological processes, and in preclinical studies to evaluate potential therapeutic strategies. Some common examples of cell-specific depletion using antibodies include depletion of T cells in immunology research, depletion of cancer cells in oncology research, and depletion of neurons in neurobiology research.