Mouse IL5RA Recombinant Protein (RPPB0521)
- SKU:
- RPPB0521
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P21183
- Research Area:
- Cytokines
Frequently bought together:
Description
| Product Name: | Mouse IL5RA Recombinant Protein |
| Product Code: | RPPB0521 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL5RA |
| Synonyms: | Interleukin-5 receptor subunit alpha, IL-5 receptorsubunit alpha, IL-5R subunit alpha, IL-5R-alpha, IL-5RA, CD125. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL5RA protein solution (0.5mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% asdetermined by SDS-PAGE. |
| Amino Acid Sequence: | DLLNHKKFLL LPPVNFTIKA TGLAQVLLHW DPNPDQEQRH VDLEYHVKINAPQEDEYDTR KTESKCVTPL HEGFAASVRT ILKSSHTTLA SSWVSAELKA PPGSPGTSVT NLTCTTHTVVSSHTHLRPYQ VSLRCTWLVG KDAPEDTQYF LYYRFGVLTE KCQEYSRDAL NRNTACWFPRTFINSKGFEQ LAVHINGSSKRAAIKPFDQL FSPLAIDQVN PPRNVTVEIE SNSLYIQWEK PLSAFPDHCF NYELKIYNTK NGHIQKEKLI ANKFISKIDDVSTYSIQVRA AVSSPCRMPG RWGEWSQPIY VGKERKSLVE WHLEHHHHHH |
Interleukin-5 receptor subunit alpha (Il5ra) regulates the development and function of eosinophils. The Il5ra protein is a therapeutic target for hypereosinophilic diseases including allergic inflammations and asthma. Oct2 enhances antibody-secreting cell differentiation via regulation of Il5ra chain expression on activated B cells.
IL5RA Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 330 amino acids (18-339a.a.) and having a molecular mass of 37.8kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).IL5RA is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL5RA: This is the receptor for interleukin-5. The alpha chain binds to IL5. Belongs to the type I cytokine receptor family. Type 5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, cytokineChromosomal Location of Human Ortholog: 6 E1|6 49.19 cMCellular Component: integral component of membrane; membraneMolecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activityBiological Process: cellular response to organic substance; inflammatory response to antigenic stimulus; regulation of interleukin-5 production |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P21183 |
| NCBI GenInfo Identifier: | 6680431 |
| NCBI Gene ID: | 16192 |
| NCBI Accession: | NP_032396.1 |
| UniProt Secondary Accession: | P21183 |
| UniProt Related Accession: | P21183 |
| Molecular Weight: | |
| NCBI Full Name: | interleukin-5 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 5 receptor, alpha |
| NCBI Official Symbol: | Il5ra�� |
| NCBI Official Synonym Symbols: | Il5r; CD125; CDw125�� |
| NCBI Protein Information: | interleukin-5 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-5 receptor subunit alpha |
| UniProt Synonym Protein Names: | CD_antigen: CD125 |
| Protein Family: | Interleukin-5 receptor |
| UniProt Gene Name: | Il5ra�� |
| UniProt Entry Name: |
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