Mouse IL31 Recombinant Protein (RPPB0658)
- SKU:
- RPPB0658
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q6EAL8
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL31 Recombinant Protein |
| Product Code: | RPPB0658 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | IL31 |
| Synonyms: | Interleukin 31, IL31, IL-31. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The IL31 (1mg/ml) was lyophilized from 10mM sodium Phosphate pH-7.5. |
| Solubility: | It is recommended to reconstitute the lyophilized IL31 in sterile 18M? -cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL31 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL31 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C |
IL-31 produced by activated Th2-type T cells, cooperates with a heterodimeric receptor consisting of IL-31 Receptor Anatagonist and Onconstatin-M Receptor that is continuesly expressed on epithelial cells and keratinocytes. IL-31 plays a role in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma. IL-31 is involved in the itching sensation and endorses the scratching behavior in NC/Nga mice with atopic dermatitis. IL-31 expression is connectd with CLA(+) T cells and contributes to the development of atopic dermatitis-induced skin inflammation and pruritus. IL-31 is a powerful inducer of proinflammatory mediators in human colonic SEMFs. IL-31 takes part as a proinflammatory cytokine derived from Th2 cells.Serum IL-31 level is higher in patients with atopic dermatitis. IL-31 is involved in a broad range of immune- & non-immune cells & possesses potential pleiotropic physiological functions, including regulating hematopoiesis & immune re
IL31 mouse recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 141 amino acids and having a molecular mass of 15.7 kDa.
| UniProt Protein Function: | IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunityProtein type: Cytokine; Secreted, signal peptide; SecretedCellular Component: extracellular space; extracellular regionMolecular Function: cytokine activityBiological Process: immune system process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6EAL8 |
| NCBI GenInfo Identifier: | 81863672 |
| NCBI Gene ID: | 76399 |
| NCBI Accession: | Q6EAL8.1 |
| UniProt Secondary Accession: | Q6EAL8 |
| UniProt Related Accession: | Q6EAL8 |
| Molecular Weight: | 18,120 Da |
| NCBI Full Name: | Interleukin-31 |
| NCBI Synonym Full Names: | interleukin 31 |
| NCBI Official Symbol: | Il31�� |
| NCBI Official Synonym Symbols: | 1700013B14Rik�� |
| NCBI Protein Information: | interleukin-31; IL-31 |
| UniProt Protein Name: | Interleukin-31 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il31�� |
| UniProt Entry Name: | IL31_MOUSE |
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