Mouse IL 18 Recombinant Protein (RPPB0624)
- SKU:
- RPPB0624
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P70380
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL 18 Recombinant Protein |
| Product Code: | RPPB0624 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | IL 18 |
| Synonyms: | Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin, Il18. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless liquid formulation. |
| Formulation: | The Mouse IL-18 protein solution contains 20mM Tris-HCl pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MNFGRLHCTT AVIRNINDQV LFVDKRQPVF EDMTDIDQSA SEPQTRLIIY MYKDSEVRGL AVTLSVKDSK MSTLSCKNKI ISFEEMDPPE NIDDIQSDLI FFQKRVPGHN KMEFESSLYE GHFLACQKED DAFKLILKKK DENGDKSVMF TLTNLHQS |
IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
Interleukin-18 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 178 amino acids (36-192 a.a.) and having a molecular mass of 20.4 kDa. The Mouse IL-18 is fused to a 20 amino acids His Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family. |
| UniProt Protein Details: | Protein type:Cytokine Cellular Component: extracellular space; apical plasma membrane; cytoplasm; extracellular region Molecular Function:cytokine activity Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of smooth muscle cell migration; positive regulation of activated T cell proliferation; positive regulation of interleukin-8 production; positive regulation of superoxide release; positive regulation of neuron apoptosis; lipopolysaccharide-mediated signaling pathway; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of natural killer cell proliferation; T-helper 1 type immune response; MAPKKK cascade; interleukin-13 biosynthetic process; positive regulation of tumor necrosis factor production; sleep; positive regulation of chemokine production; positive regulation of vascular permeability; negative regulation of neutrophil apoptosis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of interferon-gamma production; induction of apoptosis via death domain receptors; response to hypoxia; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation |
| UniProt Code: | P70380 |
| NCBI GenInfo Identifier: | 3219810 |
| NCBI Gene ID: | 16173 |
| NCBI Accession: | P70380.2 |
| UniProt Related Accession: | P70380 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-18 |
| NCBI Synonym Full Names: | interleukin 18 |
| NCBI Official Symbol: | Il18�� |
| NCBI Official Synonym Symbols: | Igif; Il-18�� |
| NCBI Protein Information: | interleukin-18; IL-1 gamma; interleukin-1 gamma; IFN-gamma-inducing factor; interferon gamma-inducing factor; interferon-gamma-inducing factor |
| UniProt Protein Name: | Interleukin-18 |
| UniProt Synonym Protein Names: | Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il18�� |
| UniProt Entry Name: | IL18_MOUSE |
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