Mouse IL 17 Recombinant Protein (RPPB0608)
- SKU:
- RPPB0608
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q62386
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IL 17 Recombinant Protein |
| Product Code: | RPPB0608 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | IL 17 |
| Synonyms: | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 17 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA |
| Biological Activity: | The ED50 as determined by the dose-dependant induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts was found to be 0.4 ng/ml, corresponding to a specific activity of 2,500,000 units/mg. |
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Interleukin-17 Murine Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 268 (2x134 a.a.) amino acids and having a molecular mass of 30 kDa. The IL-17 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Cellular Component: extracellular space; cytoplasm; extracellular region; external side of plasma membrane Molecular Function:cytokine activity Biological Process: positive regulation of osteoclast differentiation; positive regulation of interleukin-23 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response |
| UniProt Code: | Q62386 |
| NCBI GenInfo Identifier: | 2498482 |
| NCBI Gene ID: | 16171 |
| NCBI Accession: | Q62386.1 |
| UniProt Secondary Accession: | Q62386,Q60971, |
| UniProt Related Accession: | Q62386 |
| Molecular Weight: | 17,490 Da |
| NCBI Full Name: | Interleukin-17A |
| NCBI Synonym Full Names: | interleukin 17A |
| NCBI Official Symbol: | Il17a�� |
| NCBI Official Synonym Symbols: | Il17; Ctla8; IL-17; Ctla-8; IL-17A�� |
| NCBI Protein Information: | interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8 |
| UniProt Protein Name: | Interleukin-17A |
| UniProt Synonym Protein Names: | Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il17a�� |
| UniProt Entry Name: | IL17_MOUSE |
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