The Mouse IL-10 Monoclonal Antibody (PE Conjugated) JES5-16E3 (AGEL2028) from Assay Genie is a powerful tool for researchers studying immune responses and cytokine signaling pathways in mouse models. This antibody is specifically designed to target and detect Interleukin-10 (IL-10), an important anti-inflammatory cytokine that plays a key role in regulating immune responses. The PE conjugation allows for easy and sensitive detection through flow cytometry and other fluorescence-based assays.IL-10 is known for its immunosuppressive functions and its ability to control inflammation, making it a crucial molecule in research related to autoimmune diseases, infectious diseases, and cancer immunology.
By using the JES5-16E3 antibody, researchers can accurately measure IL-10 expression levels in various cell types and tissues, providing valuable insights into immune regulation mechanisms.With its high specificity and reliable performance, the Mouse IL-10 Monoclonal Antibody (PE Conjugated) JES5-16E3 (AGEL2028) is an essential tool for investigating the role of IL-10 in immune modulation and disease pathogenesis.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P18893
Gene ID:
16153
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
L-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI. IL-10 inhibits IFN-γ, TNF-β, and IL-2 production by Th1 clones; inhibits macrophage-mediated IL-1, IL-6, and TNF-α synthesis; suppresses the delayed type hypersensitivity response; stimulates Th2 cell response (which results in elevated antibody production); and promotes mast cell proliferation in combination with IL-4.