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Mouse IgG2a Fc Silenced (D265A), Isotype Control - Purified No Carrier Protein (IVMB0553)

SKU:
IVMB0553
Antibody Type:
In Vivo Isotype Control
Modifications:
PE-Conjugated
Applications:
In Vivo
Disease Area:
Cancer
Clone:
C1.18.4 (D265A)
Target:
KLH
Isotype:
Mouse IgG2a k
$275 - $5,219

Description

system_update_altDatasheet
Product Name: Mouse IgG2a Fc Silenced (D265A), Isotype Control – Purified No Carrier Protein
SKU: IVMB0553
Size: 1 mg, 5 mg, 25 mg, 50 mg
Clone: C1.18.4 (D265A)
Target: KLH
Product Type: Recombinant Isotype Control
Synonyms: C1.18.4 (D265A)
Isotype: Mouse IgG2a k
Expression Host: HEK-293 Cells
FC Effector Activity: Muted
Applications: FA, FC, in vivo
Formulation: This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Product Concentration: >= 5.0 mg/ml
Purity: ≥95% by SDS Page⋅ ≥95% monomer by analytical SEC
State of Matter: Liquid
Specificity: This Mouse IgG2a (Anti-KLH) isotype control antibody has been tested against selected species' cells and tissues to assure minimal cross reactivity. This antibody was chosen as an isotype control after screening on a variety of resting, activated, live, and fixed mouse, rat and human tissue.
Immunogen: KLH
Endotoxin Level: <0.5 EU/mg as determined by the LAL method
Storage and Handling: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -80°C. Avoid Repeated Freeze Thaw Cycles.
Pathogen Testing: To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s recombinant biosimilar antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Product Preparation: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Antigen Distribution: PD-L1 is commonly expressed on the surface of antigen presenting cells (APC) and tumor cells. B7.1 is found on activated APCs including dendritic cells, macrophages, and activated B cells.

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