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Mouse IgG1 Isotype control monoclonal antibody (APC) (AGIM0221)

SKU:
AGIM0221
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG1
Clone:
1F8
Conjugation:
APC
Applications:
FC
$215
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Description

system_update_altDatasheet
Product Name:Mouse IgG1 Isotype control monoclonal antibody (APC)
Product Code:AGIM0221
Size:500 µL
Reactivity:Mouse
Clone:1F8
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P14672
Background:The specificity of staining by monoclonal antibodies to target antigens should be verified by establishing the amount of non-specific antibody binding. In general, non-reactive immunoglobulin of the same isotype is included as a negative control for each specific monoclonal antibody used in a particular immunoassay.
UniProt Protein Function:GLUT4: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK.
UniProt Protein Details:

Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: multivesicular body; trans-Golgi network transport vesicle; membrane; clathrin-coated vesicle; integral to plasma membrane; perinuclear region of cytoplasm; T-tubule; plasma membrane; endomembrane system; coated pit; vesicle membrane; cytosol; lipid raft; external side of plasma membrane

Molecular Function:D-glucose transmembrane transporter activity; protein binding; glucose transmembrane transporter activity

Biological Process: amylopectin biosynthetic process; response to ethanol; cellular response to insulin stimulus; glucose import; hexose transport; carbohydrate metabolic process; brown fat cell differentiation; pathogenesis; glucose transport; glucose homeostasis; transmembrane transport

Disease: Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
UniProt Code:P14672
NCBI GenInfo Identifier:121761
NCBI Gene ID:6517
NCBI Accession:P14672.1
UniProt Secondary Accession:P14672,Q05BQ3, Q14CX2,
UniProt Related Accession:P14672
Molecular Weight:509
NCBI Full Name:Solute carrier family 2, facilitated glucose transporter member 4
NCBI Synonym Full Names:solute carrier family 2 (facilitated glucose transporter), member 4
NCBI Official Symbol:SLC2A4  
NCBI Official Synonym Symbols:GLUT4  
NCBI Protein Information:solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; insulin-responsive glucose transporter type 4; glucose transporter type 4, insulin-responsive
UniProt Protein Name:Solute carrier family 2, facilitated glucose transporter member 4
UniProt Synonym Protein Names:Glucose transporter type 4, insulin-responsive; GLUT-4
UniProt Gene Name:SLC2A4  
UniProt Entry Name:GTR4_HUMAN

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