Mouse IFN b Recombinant Protein (RPPB0395)
- SKU:
- RPPB0395
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P01575
- Research Area:
- Cytokines
Description
| Product Name: | Mouse IFN b Recombinant Protein |
| Product Code: | RPPB0395 |
| Size: | 25µg |
| Species: | Mouse |
| Target: | IFN b |
| Synonyms: | Leukocyte IFN, B cell IFN, Type I IFN, IFNB1, IFB, IFF, IFNB, IFN-b 1b, MGC96956. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The IFN-Beta (0.25mg/ml) contains 20mM HEPES (pH6.0), 0.5M NaCl, 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MINYKQLQLQ ERTNIRKCQE LLEQLNGKIN LTYRADFKIP MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI VVRLLDELHQ QTVFLKTVLE EKQEERLTWE MSSTALHLKS YYWRVQRYLK LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF QN |
IFN-beta 1b has antiviral, antibacterial and anticancer activities.Influenza A viruses not only inhibit IFN-beta gene induction but also supress Type-I IFN signaling via mechanism involving induction of the SOCS-3 protein.Intracellular bacteria and cytosolic poly (dA-dT) trigger IFN-beta responses in different human cells without requiring human ZBP1.
IFN beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (22-182 a.a.) and having a molecular mass of 22 kDa. Mouse IFN beta is fused to 21 amino acid at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular space; extracellular region Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interferon-alpha/beta receptor binding; cytokine activity Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; defense response; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; negative regulation of viral genome replication; B cell differentiation; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein |
| UniProt Code: | P01575 |
| NCBI GenInfo Identifier: | 6754304 |
| NCBI Gene ID: | 15977 |
| NCBI Accession: | NP_034640.1 |
| UniProt Related Accession: | P01575 |
| Molecular Weight: | 22,127 Da |
| NCBI Full Name: | interferon beta |
| NCBI Synonym Full Names: | interferon beta 1, fibroblast |
| NCBI Official Symbol: | Ifnb1�� |
| NCBI Official Synonym Symbols: | Ifb; IFNB; IFN-beta�� |
| NCBI Protein Information: | interferon beta |
| UniProt Protein Name: | Interferon beta |
| Protein Family: | Interferon |
| UniProt Gene Name: | Ifnb1�� |
| UniProt Entry Name: | IFNB_MOUSE |
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