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APC Anti-Mouse/Human CD11b Antibody [M1/70] (AGEL0308)

Datasheet MSDS
SKU AGEL0308
Product Type Antibody
Antibody Type Monoclonal Antibody
Host Species Rat
Isotype IgG2b
Clone M1/70
Conjugation APC
Applications FC
€28 - €87

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse/Human CD11b Antibody [M1/70]

The mouse/human CD11b Monoclonal Antibody (APC Conjugated, M1/70) provided by AssayGenie is a highly specific and reliable tool for examining CD11b expression in both mouse and human samples. The antibody, conjugated with allophycocyanin (APC), allows for easy visualization and analysis of CD11b, a cell surface marker primarily found on myeloid cells such as monocytes, macrophages, and granulocytes.By targeting the CD11b protein, this monoclonal antibody enables accurate detection and quantification of these important immune cells, making it an ideal choice for flow cytometry and immunofluorescence applications. The M1/70 antibody is rigorously validated to ensure high sensitivity and specificity, providing researchers with confidence in their experimental results.

CD11b plays a crucial role in immune responses, including phagocytosis, cell adhesion, and migration to sites of inflammation. Dysregulation of CD11b expression has been implicated in various diseases, such as inflammatory disorders, infections, and cancer. Therefore, investigating CD11b expression and function is essential for advancing our understanding of immune system dynamics and developing targeted therapeutic strategies.Overall, the mouse/human CD11b Monoclonal Antibody (APC Conjugated, M1/70) from AssayGenie is a valuable tool for researchers studying immune cell biology, inflammation, and related diseases in both mouse and human systems.

Product Title:APC Anti-Mouse/Human CD11b Antibody [M1/70]
SKU:AGEL0308
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M1/70
Synonyms:Integrin alpha-M;Itgam;CD11 antigen-like family member B;CR-3 alpha chain;Leukocyte adhesion receptor MO1;CD11b;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P05555 P11215
Gene ID:16409,3684
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.
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