Mouse GRO b Recombinant Protein (RPPB1148)
- SKU:
- RPPB1148
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P10889
- Research Area:
- Chemokines
Description
| Product Name: | Mouse GRO b Recombinant Protein |
| Product Code: | RPPB1148 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | GRO b |
| Synonyms: | Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine (C-X-C motif) ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized GRO-beta Mouse in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CXCL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN |
| Biological Activity: | The Biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 105-106units/mg. |
Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
GRO-Beta Mouse Recombinant also caled mouse MIP-2 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7849 Dalton. The CXCL2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P10889 |
| NCBI GenInfo Identifier: | 127100 |
| NCBI Gene ID: | 20310 |
| NCBI Accession: | P10889.2 |
| UniProt Secondary Accession: | P10889 |
| UniProt Related Accession: | P10889 |
| Molecular Weight: | 10,621 Da |
| NCBI Full Name: | C-X-C motif chemokine 2 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 2 |
| NCBI Official Symbol: | Cxcl2�� |
| NCBI Official Synonym Symbols: | GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a�� |
| NCBI Protein Information: | C-X-C motif chemokine 2; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2 |
| UniProt Protein Name: | C-X-C motif chemokine 2 |
| UniProt Synonym Protein Names: | Macrophage inflammatory protein 2; MIP2 |
| Protein Family: | C-X-C motif chemokine |
| UniProt Gene Name: | Cxcl2�� |
| UniProt Entry Name: | CXCL2_MOUSE |
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