Mouse GOT1 Recombinant Protein (RPPB1724)
- SKU:
- RPPB1724
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P05201
- Research Area:
- Enzymes
Frequently bought together:
Description
| Product Name: | Mouse GOT1 Recombinant Protein |
| Product Code: | RPPB1724 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | GOT1 |
| Synonyms: | Aspartate aminotransferase, cytoplasmic, cAspAT, Cysteineaminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT,Glutamate oxaloacetate transaminase 1, Transaminase A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | GOT1 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAPPSVF AQVPQAPPVL VFKLTADFRD DPDPRKVNLG VGAYRTDESQPWVLPVVRKV EQKIANDNSL NHEYLPILGL AEFRSCASRL VLGDNSPAIR ENRVGGVQSL GGTGALRIGADFLGRWYNGT DNKNTPIYVS SPTWENHNAV FSAAGFKDIR PYCYWDAEKR GLDLQGFLND LENAPEFSIF VLHACAHNPT GTDPTPEQWKQIAAVMQRRF LFPFFDSAYQ GFASGDLEKD AWAIRYFVSE GFELFCAQSF SKNFGLYNER VGNLTVVGKESDSVLRVLSQ MEKIVRITWS NPPAQGARIV AATLSDPELF KEWKGNVKTM ADRILTMRSE LRARLEALKT PGTWSHITEQIGMFSFTGLN PKQVEYLVNE KHIYLLPSGR INMCGLTTKN LDYVATSIHE AVTKIQ |
GOT1 is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, which participate in amino acid metabolism and the urea and tricarboxylic acid cycles. Both enzymes are homodimeric and show close homology.
GOT1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 436 amino acids (1-413a.a) andhaving a molecular mass of 48.6kDa.GOT1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. |
| UniProt Code: | P05201 |
| NCBI GenInfo Identifier: | 160298209 |
| NCBI Gene ID: | 14718 |
| NCBI Accession: | NP_034454.2 |
| UniProt Secondary Accession: | P05201,Q3UJH8, |
| UniProt Related Accession: | P05201 |
| Molecular Weight: | 46,248 Da |
| NCBI Full Name: | aspartate aminotransferase, cytoplasmic |
| NCBI Synonym Full Names: | glutamic-oxaloacetic transaminase 1, soluble |
| NCBI Official Symbol: | Got1�� |
| NCBI Official Synonym Symbols: | cCAT; Got-1; cAspAT; AI789014�� |
| NCBI Protein Information: | aspartate aminotransferase, cytoplasmic |
| UniProt Protein Name: | Aspartate aminotransferase, cytoplasmic |
| UniProt Synonym Protein Names: | Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A |
| Protein Family: | Allatostatin |
| UniProt Gene Name: | Got1�� |
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