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PE/Cyanine7 Anti-Mouse CD8a Antibody [53-6.7] (AGEL1341)

SKU:
AGEL1341
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
53-7.6
Conjugation:
PE/Cy7
€159 - €349
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD8a Antibody [53-6.7]

The Mouse CD8a Monoclonal Antibody (PE-Cyanine7 Conjugated) is a powerful tool for researchers studying immune cell interactions and responses. This antibody, designated as 53-7.6 (AGEL1341), specifically targets the CD8a marker found on cytotoxic T cells, a crucial component of the immune system responsible for identifying and destroying infected or abnormal cells.Through its PE-Cyanine7 conjugation, this antibody allows for highly sensitive flow cytometry analysis, enabling researchers to accurately quantify and characterize CD8a-positive cell populations. Its monoclonal nature ensures consistent and reliable performance across experiments, resulting in reproducible data for further study.

The CD8a marker is essential for understanding the function and dynamics of cytotoxic T cells in immune responses, inflammation, and various diseases, including infections and cancers. By utilizing this antibody, researchers can delve deeper into the mechanisms underlying T cell-mediated immunity and develop targeted approaches for immunotherapy and vaccine development.Overall, the Mouse CD8a Monoclonal Antibody (PE-Cyanine7 Conjugated) 53-7.6 (AGEL1341) is a valuable resource for immunologists, oncologists, and researchers exploring the complex interplay between the immune system and various pathological conditions.

Product Title:PE/Cyanine7 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL1341
Size:25µg, 100µg
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

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