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APC Anti-Mouse CD86 Antibody [GL-1] (AGEL0041)

SKU:
AGEL0041
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
GL-1
Conjugation:
APC
Applications:
FC
$215 - $503
Frequently bought together:

Description

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APC Anti-Mouse CD86 Antibody [GL-1]

The APC-Conjugated Mouse CD86 Monoclonal Antibody (GL-1) is expertly designed for research involving CD86, a key cell surface molecule essential for immune response modulation and costimulatory signaling. This monoclonal antibody, produced in mice, is highly specific to mouse CD86 and is validated for use in flow cytometry applications. The allophycocyanin (APC) conjugation provides bright and stable red fluorescence, ensuring precise and reliable detection.CD86, also known as B7-2, plays a critical role in the activation of T cells and the modulation of immune responses by interacting with CD28 and CTLA-4 receptors. Its importance in immune regulation makes it a valuable target for research into cancer, autoimmune disorders, and chronic inflammatory conditions.

The APC-Conjugated Mouse CD86 Monoclonal Antibody (GL-1) is an indispensable tool for researchers aiming to elucidate the mechanisms of immune activation and develop therapies that modulate immune function.By providing accurate and sensitive detection of CD86, this antibody supports comprehensive studies of immune pathways, contributing to the advancement of immunotherapy and the development of innovative treatments for immune-related diseases. Understanding the activity of CD86 is crucial for creating targeted therapies that harness or modulate immune function, making this antibody a vital asset for advancing research in immunology and cancer.

Product Title:APC Anti-Mouse CD86 Antibody [GL-1]
SKU:AGEL0041
Size:50 Tests, 100 Tests, 200 Tests
Clone No:GL-1
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P42082
Gene ID:12524
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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