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GenieFluor 488 Anti-Mouse CD86 Antibody [GL-1] (AGEL0559)

SKU:
AGEL0559
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€199 - €409
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD86 Antibody [GL-1]

The Mouse CD86 Monoclonal Antibody (AF488 Conjugated, GL-1) is a highly specific antibody designed for research purposes involving the immune molecule CD86. This monoclonal antibody, conjugated with AF488 for fluorescence-based applications, is rigorously validated for use in various experimental techniques, including flow cytometry and immunofluorescence assays.CD86, also known as B7-2, is a critical co-stimulatory molecule expressed on antigen-presenting cells that plays a key role in T-cell activation and immune response regulation. The precise targeting and detection of CD86 using this monoclonal antibody enable researchers to explore its involvement in immune signaling pathways, autoimmune disorders, transplantation immunology, and infectious diseases.

Additionally, the conjugation with AF488 facilitates visualizing CD86 expression in different cell types, offering valuable insights into immune cell interactions and responses.With its high specificity and sensitivity, the Mouse CD86 Monoclonal Antibody (AF488 Conjugated, GL-1) is an essential tool for investigations in immunology, cell biology, and disease models. It provides researchers with the capability to study the role of CD86 in immune modulation and host defense mechanisms, paving the way for potential therapeutic interventions and advancements in the field of immunotherapy.

Product Title:GenieFluor 488 Anti-Mouse CD86 Antibody [GL-1]
SKU:AGEL0559
Size:25µg, 100µg
Clone No:GL-1
Synonyms:T-lymphocyte activation antigen CD86;Cd86;Activation B7-2 antigen;Early T-cell costimulatory molecule 1;ETC-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P42082
Gene ID:12524
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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