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PE/Cyanine7 Anti-Mouse CD80 Antibody [16-10A1] (AGEL0527)

SKU:
AGEL0527
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
$299 - $683

Description

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PE/Cyanine7 Anti-Mouse CD80 Antibody [16-10A1]

The Mouse CD80 Monoclonal Antibody (PE/Cyanine7 Conjugated, 16-10A1) offered by AssayGenie (AGEL0527) is a high-quality reagent designed for research involving the CD80 protein, a critical co-stimulatory molecule involved in T cell activation and immune response regulation. This antibody, derived from mouse monoclonal sources, is specifically conjugated with PE/Cyanine7 for enhanced detection capabilities in flow cytometry and immunofluorescence applications.CD80, also known as B7-1, serves as a ligand for the T cell receptor CD28 and is essential for the initiation and regulation of adaptive immune responses. By binding to CD80, this antibody enables precise detection and analysis of CD80 expression on various cell types, facilitating detailed investigations in immunology, vaccine development, and autoimmune disease research.

The role of CD80 in the modulation of T cell activation and tolerance makes it a key target for understanding immune responses in various physiological and pathological conditions. This antibody provides researchers with a valuable tool to study the intricate interactions involving CD80, paving the way for advancements in immunotherapy, vaccination strategies, and treatment approaches for immune-related disorders.

Product Title:PE/Cyanine7 Anti-Mouse CD80 Antibody [16-10A1]
SKU:AGEL0527
Size:50 Tests, 100 Tests, 200 Tests
Clone No:16-10A1
Synonyms:T-lymphocyte activation antigen CD80;Cd80;Activation B7-1 antigen;B7;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:PE/Cyanine7 Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q00609
Gene ID:12519
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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