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PE Anti-Mouse CD80 Antibody [16-10A1] (AGEL0525)

SKU:
AGEL0525
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
$179 - $431
Frequently bought together:

Description

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PE Anti-Mouse CD80 Antibody [16-10A1]

The Mouse CD80 Monoclonal Antibody PE Conjugated (16-10A1) is a powerful tool for research involving CD80, a key co-stimulatory molecule essential for T cell activation and immune response regulation. This monoclonal antibody, conjugated with PE for easy detection, is specifically designed to target CD80 in mouse samples, making it ideal for flow cytometry and antibody labeling experiments.CD80, also known as B7-1, plays a pivotal role in modulating the immune response by providing the essential second signal required for T cell activation. Its interaction with CD28 on T cells is crucial for initiating immune responses and maintaining immune tolerance.

Studying the expression and function of CD80 is essential for understanding immune activation, tolerance, and the development of immune-based therapies.This monoclonal antibody offers high specificity and sensitivity in detecting CD80, allowing for accurate analysis of its expression levels on various cell types, particularly antigen-presenting cells. Researchers in immunology, vaccine development, and autoimmune disease studies will find this antibody invaluable for investigating the role of CD80 in immune regulation and its potential as a therapeutic target.

Product Title:PE Anti-Mouse CD80 Antibody [16-10A1]
SKU:AGEL0525
Size:50 Tests, 100 Tests, 200 Tests
Clone No:16-10A1
Synonyms:T-lymphocyte activation antigen CD80;Cd80;Activation B7-1 antigen;B7;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:PE Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q00609
Gene ID:12519
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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