The Mouse CD73 Monoclonal Antibody (FITC Conjugated, TY-23) is a specialized tool designed for researchers investigating CD73, a key enzyme involved in purine metabolism and immune response regulation. This monoclonal antibody, produced using innovative technology, is specifically conjugated with FITC for fluorescence-based applications, allowing for precise and efficient detection of CD73 in various experimental settings.CD73, also known as ecto-5'-nucleotidase, plays a crucial role in the production of adenosine, a molecule with potent immunoregulatory properties. By catalyzing the conversion of AMP to adenosine, CD73 modulates immune responses, inflammation, and tissue repair processes.
The availability and activity of CD73 have been linked to various diseases, including cancer, inflammatory disorders, and autoimmune conditions, making it a promising target for therapeutic interventions.This FITC-conjugated monoclonal antibody, clone TY-23, offers high specificity and sensitivity in detecting CD73 expression in mouse samples, enabling researchers to explore the functions and dynamics of this enzyme in diverse biological contexts. Whether studying immune cell populations, tumor microenvironments, or therapeutic strategies targeting CD73, this antibody provides a reliable tool for in vitro and in vivo investigations in immunology, oncology, and related fields.
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
Q61503
Gene ID:
23959
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD73 (ecto-5`-nucleotidase) is a 69 kD GPI-anchored surface protein. In mice, expression of CD73 in bone marrow is restricted to CD11b+ myeloid cells. In spleen, it is largely expressed on T cells.