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GenieFluor 488 Anti-Mouse CD62L Antibody [Mel14] (AGEL0091)

SKU:
AGEL0091
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
Mel14
Conjugation:
AF 488
Applications:
FC
$167 - $359
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody (ALEXA FLUOR 488 Conjugated, Mel14 - AGEL0091) is an essential tool for researchers studying immune responses and cell adhesion in mice. This antibody specifically targets CD62L, a crucial cell surface molecule involved in lymphocyte homing and migration.The antibody is monoclonal, meaning it is derived from a single clone of cells that produce antibodies targeting CD62L. By conjugating it with ALEXA FLUOR 488, researchers can visualize the localization and expression of CD62L in mouse tissues with high sensitivity and specificity.CD62L, also known as L-selectin, plays a pivotal role in the immune system by facilitating the migration of lymphocytes to secondary lymphoid organs.

Its expression levels and activity are indicative of immune cell activation and trafficking, making it a valuable marker for studying immune responses in various experimental settings.This antibody, Mel14 - AGEL0091, is rigorously validated for its specificity and functionality in applications such as flow cytometry and immunofluorescence. Researchers can rely on its performance to accurately detect and quantify CD62L expression in diverse cell populations and tissues, making it an invaluable tool for immunologists and researchers investigating immune cell behavior in mouse models.

Product Title:GenieFluor 488 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0091
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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