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GenieFluor 647 Anti-Mouse CD62L Antibody [Mel14] (AGEL0633)

SKU:
AGEL0633
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€139 - €299
Frequently bought together:

Description

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GenieFluor 647 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody (AF647 Conjugated, Mel14) is a specialized tool for researchers studying immune cell adhesion and migration processes. This antibody, derived from mouse monoclonal sources, is designed to target CD62L, also known as L-selectin, a crucial adhesion molecule involved in lymphocyte homing and trafficking.CD62L is a key receptor expressed on the surface of lymphocytes, facilitating their entry into secondary lymphoid organs and interactions with high endothelial venules. The AF647 conjugation of this antibody allows for fluorescent detection, making it particularly suitable for flow cytometry and immunofluorescence applications in tracking CD62L expression on different immune cell populations.

By specifically binding to CD62L, researchers can investigate the role of this adhesion molecule in immune responses, inflammation, and immune cell activation. The ability to visualize and quantify CD62L expression provides valuable insights into the mechanisms underlying immune cell migration and immune system function.Overall, the Mouse CD62L Monoclonal Antibody (AF647 Conjugated, Mel14) offers a reliable and powerful tool for immunologists, cell biologists, and researchers studying immune cell dynamics and interactions in various physiological and pathological contexts.

Product Title:GenieFluor 647 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0633
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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