Anti-Mouse CD54 Antibody (APC) (AGIM0558)

Mouse CD54 monoclonal antibody (APC) (AGIM0558)

SKU:

AGIM0558

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Mouse

Host Species:

Rat

Isotype:

IgG2b

Clone:

YN1.7.4

Conjugation:

APC

Applications:

Description

Description

Datasheet

Isotype:	IgG2b
Host Species:	Rat
Storage:	Store at 4°C. Avoid prolonged exposure to light.
Uniprot:	P05362
Background:	CD54 (ICAM-1) is a member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.

UniProt Protein Function:	ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.
UniProt Protein Details:	Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19p13.3-p13.2 Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane Molecular Function:viral receptor activity; integrin binding; protein binding; transmembrane receptor activity; receptor activity Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration Disease: Malaria, Susceptibility To
NCBI Summary:	This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
UniProt Code:	P05362
NCBI GenInfo Identifier:	68067956
NCBI Gene ID:	3383
NCBI Accession:	P05362.2
UniProt Secondary Accession:	P05362,Q5NKV7, Q96B50, B2R6M3,
UniProt Related Accession:	P05362
Molecular Weight:
NCBI Full Name:	Intercellular adhesion molecule 1
NCBI Synonym Full Names:	intercellular adhesion molecule 1
NCBI Official Symbol:	ICAM1
NCBI Official Synonym Symbols:	BB2; CD54; P3.58
NCBI Protein Information:	intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
UniProt Protein Name:	Intercellular adhesion molecule 1
UniProt Synonym Protein Names:	Major group rhinovirus receptor; CD_antigen: CD54
Protein Family:	Intercellular adhesion molecule
UniProt Gene Name:	ICAM1
UniProt Entry Name:	ICAM1_HUMAN