Biotin Anti-Mouse CD49b Antibody [DX5] (AGEL0436)
- SKU:
- AGEL0436
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- IgM
- Clone:
- DX5
- Conjugation:
- Biotin
- Applications:
- FC
Frequently bought together:
Description
Product Title: | Biotin Anti-Mouse CD49b Antibody [DX5] |
SKU: | AGEL0436 |
Size: | 25µg, 100µg |
Clone No: | DX5 |
Synonyms: | Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b; |
Host Species: | Rat |
Reactivity: | Mouse |
Application: | FCM |
Isotype: | Rat IgM, κ |
Isotype Control: | Biotin Rat IgM, κ Isotype Control[RTK2118] |
Form: | Liquid |
Conjugation: | Biotin |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Swissprot: | Q62469 |
Gene ID: | 16398 |
Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen. |