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APC Anti-Mouse CD49b Antibody [DX5] (AGEL0439)

SKU:
AGEL0439
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgM
Clone:
DX5
Conjugation:
APC
Applications:
FC
€139 - €289
Frequently bought together:

Description

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APC Anti-Mouse CD49b Antibody [DX5]

The Mouse CD49b Monoclonal Antibody (APC Conjugated, DX5) is a powerful tool for researchers studying immune cell markers and cell adhesion molecules in mouse models. This antibody, labeled with allophycocyanin (APC), specifically targets CD49b, also known as DX5, a surface marker associated with natural killer cells and subsets of T and B cells in mice.Ideal for flow cytometry applications, this monoclonal antibody enables precise identification and analysis of CD49b-expressing cells in various tissues and experimental settings. Its high specificity and sensitivity make it invaluable for investigating immune responses, cell trafficking, and immune cell interactions in immunology and cancer research.

CD49b, a subunit of the VLA-2 integrin receptor, plays a crucial role in cell adhesion and migration, contributing to immune surveillance and immune-mediated responses. Understanding the expression and function of CD49b in immune cell populations is essential for unraveling the mechanisms underlying immune regulation and immune-mediated diseases in mouse models.By utilizing the Mouse CD49b Monoclonal Antibody (APC Conjugated, DX5), researchers can delve deeper into the complexities of mouse immune responses, paving the way for insights into immune cell dynamics, immune system dysregulation, and potential therapeutic targets in various disease contexts.

Product Title:APC Anti-Mouse CD49b Antibody [DX5]
SKU:AGEL0439
Size:50 Tests, 100 Tests, 200 Tests
Clone No:DX5
Synonyms:Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:APC Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q62469
Gene ID:16398
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

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