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Mouse CD48 monoclonal antibody (APC) (AGIM0556)

SKU:
AGIM0556
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG
Clone:
HM48-1
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:Mouse CD48 monoclonal antibody (APC)
Product Code:AGIM0556
Size:100 µL
Reactivity:Mouse
Clone:HM48-1
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG
Host Species:Hamster
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P18181
Background:CD48, a member of the SLAM family and Ig superfamily, is a 45 kDa GPI-linked glycoprotein expressed on the majority of hematopoietic cells. Recent publications have reported differential expression of members of the SLAM family including CD48, CD150, and CD244 among functionally distinct bone marrow hematopoietic progenitors providing a useful tool for prediction of the primitiveness of hematopoietic progenitors based on the expression of these SLAM family members. Hematopoietic stem cells (HSC) are highly purified as CD150(+)CD244(-)CD48(-) cells while non-self-renewing multipotent hematopoietic progenitors (MPP) are CD244(+)CD150(-)CD48(-) and the most restricted progenitors are CD48(+)CD244(+)CD150(-). CD48 plays a critical role in adhesion and T cell activation. In the mouse, the primary counter-receptors for CD48 are CD2 and CD244. HM48-1 is reported to modulate in vitro and in vivo CD48 functions including blocking the CD48/CD2 and CD48/CD244 interactions, inhibiting the proliferative response of mitogen-activated spleen cells, providing a costimulation signal for T cells activated in vitro through their TCR, and prolonging cardiac allograft survival in vivo.
UniProt Protein Function:CD48: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Cellular Component: protein complex; anchored to plasma membrane; membrane; plasma membrane; integral to membrane; lipid raft; external side of plasma membrane

Molecular Function:protein binding; receptor activity; antigen binding

Biological Process: T cell activation; signal transduction; mast cell activation

UniProt Code:P18181
NCBI GenInfo Identifier:114872
NCBI Gene ID:12506
NCBI Accession:P18181.1
UniProt Secondary Accession:P18181,Q545K2,
UniProt Related Accession:P18181
Molecular Weight:27,383 Da
NCBI Full Name:CD48 antigen
NCBI Synonym Full Names:CD48 antigen
NCBI Official Symbol:Cd48  
NCBI Official Synonym Symbols:BCM1; BLAST; Bcm-1; BLAST1; SLAMF2; Sgp-60; BLAST-1; MEM-102; AI449234; AW610730  
NCBI Protein Information:CD48 antigen; HM48-1; BCM1 surface antigen; SLAM family member 2; MRC OX-45 surface antigen; signaling lymphocytic activation molecule 2
UniProt Protein Name:CD48 antigen
UniProt Synonym Protein Names:BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; sgp-60; CD_antigen: CD48
Protein Family:CD48 antigen
UniProt Gene Name:Cd48  
UniProt Entry Name:CD48_MOUSE

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