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Mouse CD45 monoclonal antibody (PE) (AGIM0531)

SKU:
AGIM0531
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG1/??
Clone:
IBL-5/25
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:Mouse CD45 monoclonal antibody (PE)
Product Code:AGIM0531
Size:100 µL
Reactivity:Mouse
Clone:IBL-5/25
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1/??
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:Q14761
Background:CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
UniProt Protein Function:PTPRCAP: Interacts with CD45/PTPRC.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: plasma membrane

Biological Process: defense response

NCBI Summary:The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]
UniProt Code:Q14761
NCBI GenInfo Identifier:22001841
NCBI Gene ID:5790
NCBI Accession:Q14761.1
UniProt Secondary Accession:Q14761,O00643, Q6I9S6, B2R512,
UniProt Related Accession:Q14761
Molecular Weight:21kDa
NCBI Full Name:Protein tyrosine phosphatase receptor type C-associated protein
NCBI Synonym Full Names:protein tyrosine phosphatase, receptor type C associated protein
NCBI Official Symbol:PTPRCAP  
NCBI Official Synonym Symbols:LPAP; CD45-AP  
NCBI Protein Information:protein tyrosine phosphatase receptor type C-associated protein
UniProt Protein Name:Protein tyrosine phosphatase receptor type C-associated protein
UniProt Synonym Protein Names:CD45-associated protein; CD45-AP; Lymphocyte phosphatase-associated phosphoprotein
Protein Family:Protein tyrosine phosphatase receptor type C-associated protein
UniProt Gene Name:PTPRCAP  

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