Mouse CD40 Recombinant Protein (RPPB3073)
- SKU:
- RPPB3073
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P27512
- Research Area:
- CD Antigens
Description
| Product Name: | Mouse CD40 Recombinant Protein |
| Product Code: | RPPB3073 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | CD40 |
| Synonyms: | Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CD40 protein solution (1.0mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | LGQCVTCSDKQYLHDGQCCD LCQPGSRLTS HCTALEKTQC HPCDSGEFSA QWNREIRCHQ HRHCEPNQGL RVKKEGTAESDTVCTCKEGQ HCTSKDCEAC AQHTPCIPGF GVMEMATETT DTVCHPCPVG FFSNQSSLFE KCYPWTSCEDKNLEVLQKGT SQTNVICGLK SRMRHHHHHH |
CD40 belongs to the TNF-receptor super family. CD40 has been found to be vital in mediating a wide range of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be essential for amyloid-beta-induced microglial activation, and therefore is considered to be an early event in Alzheimer disease pathogenesis.
CD40 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 180 amino acids (20-193 a.a.) andhaving a molecular mass of 20.1kDa (Migrates at 18-28kDa on SDS-PAGE underreducing conditions).CD40 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Cellular Component: extracellular space; cell surface; membrane; intracellular membrane-bound organelle; cell; cytoplasm; integral to membrane; plasma membrane; extracellular region; external side of plasma membrane Molecular Function:protein binding; enzyme binding; ubiquitin protein ligase binding; antigen binding Biological Process: positive regulation of isotype switching to IgG isotypes; regulation of immune response; B cell activation; immune system process; positive regulation of interleukin-12 production; immune response-regulating cell surface receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; positive regulation of MAP kinase activity; positive regulation of tyrosine phosphorylation of Stat1 protein; protein kinase B signaling cascade; positive regulation of B cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; inflammatory response; defense response to virus; regulation of immunoglobulin secretion |
| UniProt Code: | P27512 |
| NCBI GenInfo Identifier: | 172046819 |
| NCBI Gene ID: | 21939 |
| NCBI Accession: | P27512.3 |
| UniProt Secondary Accession: | P27512,Q3TS33, Q3TSL2, Q3U799, Q3U7C9, Q3UBH3, Q542B1 Q8K2X6, Q99NE0, Q99NE1, Q99NE2, Q99NE3, |
| UniProt Related Accession: | P27512 |
| Molecular Weight: | 28,878 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 5 |
| NCBI Synonym Full Names: | CD40 antigen |
| NCBI Official Symbol: | Cd40�� |
| NCBI Official Synonym Symbols: | IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5; AI326936�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 5; CD40L receptor; B-cell surface antigen CD40; T-cell differentiation antigen; tumor necrosis factor receptor superfamily, member 5 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 5 |
| UniProt Synonym Protein Names: | B-cell surface antigen CD40; Bp50; CD40L receptor; CD_antigen: CD40 |
| Protein Family: | CD40 ligand |
| UniProt Gene Name: | Cd40�� |
| UniProt Entry Name: | TNR5_MOUSE |
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