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PE/Cyanine5.5 Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL0778)

SKU:
AGEL0778
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€259 - €609
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]

The Mouse CD40 Monoclonal Antibody (PE-Cyanine5.5 Conjugated) FGK4.5 (AGEL0778) is an essential tool for research involving the CD40 protein, a critical cell surface receptor involved in immune responses and signaling. This antibody, developed as a mouse monoclonal antibody conjugated to PE-Cyanine5.5 for fluorescence applications, is specifically designed to target the CD40 antigen, enabling precise detection and analysis in various experimental settings.CD40, a member of the tumor necrosis factor receptor superfamily, plays a pivotal role in regulating immune responses, particularly in the context of antigen presentation, B-cell activation, and immune cell communication. By binding to CD40, this monoclonal antibody allows researchers to investigate the expression levels and localization of CD40 in various cell types, shedding light on its function in immune regulation and inflammatory processes.

The versatility of this antibody makes it an invaluable tool for studies in immunology, cancer research, and autoimmune diseases, where CD40 signaling pathways are implicated in disease progression and immune dysregulation. By utilizing this monoclonal antibody, researchers can further explore the mechanisms underlying CD40-mediated immune responses, paving the way for potential therapeutic interventions and targeted treatment strategies in various pathological conditions.Overall, the Mouse CD40 Monoclonal Antibody (PE-Cyanine5.5 Conjugated) FGK4.5 (AGEL0778) is a reliable reagent for robust and sensitive detection of CD40 protein, offering researchers a valuable asset in unraveling the complexities of immune signaling and response modulation.

Product Title:PE/Cyanine5.5 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
SKU:AGEL0778
Size:50 Tests, 100 Tests, 200 Tests
Clone No:FGK4.5/FGK45
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P27512
Gene ID:21939
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

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