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Mouse CD4 monoclonal antibody (APC) (AGIM0267)

SKU:
AGIM0267
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
GK1.5
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:Mouse CD4 monoclonal antibody (APC)
Product Code:AGIM0267
Size:500 µL
Reactivity:Mouse
Clone:GK1.5
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG2b
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P06332
UniProt Protein Function:CD4: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6 F2|6 59.17 cM

Cellular Component: cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; external side of plasma membrane; lipid raft; plasma membrane

Molecular Function:enzyme binding; glycoprotein binding; immunoglobulin binding; MHC class II protein binding; protein homodimerization activity; protein kinase binding; zinc ion binding

Biological Process: cell surface receptor linked signal transduction; cytokine production; defense response to Gram-negative bacterium; induction by virus of cell-cell fusion in host; maintenance of cellular protein localization; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase activity; positive regulation of T cell activation; positive regulation of T cell proliferation; regulation of T cell activation; T cell activation; T cell differentiation; T cell selection

UniProt Code:P06332
NCBI GenInfo Identifier:116015
NCBI Gene ID:12504
NCBI Accession:P06332.1
UniProt Related Accession:P06332
Molecular Weight:24,473 Da
NCBI Full Name:T-cell surface glycoprotein CD4
NCBI Synonym Full Names:CD4 antigen
NCBI Official Symbol:Cd4  
NCBI Official Synonym Symbols:L3T4; Ly-4  
NCBI Protein Information:T-cell surface glycoprotein CD4
UniProt Protein Name:T-cell surface glycoprotein CD4
UniProt Synonym Protein Names:T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; CD_antigen: CD4
Protein Family:CD40 ligand
UniProt Gene Name:Cd4  

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